Cannabis edibles are growing in popularity. They provide an alternative way to enjoy the benefits that cannabis has to offer without smoking or inhaling vapor. Edibles can be foods or beverages that contain a specific amount of cannabis in each serving and include such things as gummies, hard candies, chocolates, baked goods, granola, coffee, infused water, and more.
Just like other forms of cannabis, people use edibles for a wide variety of reasons. Depending upon the cannabis used, the edible can help you relax, ease pain, or boost your energy. For some people, however, edibles just don’t seem to work.
There’s Not Enough Cannabis
One of the main reasons why cannabis edibles might not work for you is because there just isn’t enough cannabis in the dosage you’re taking. Some individuals require higher doses than others to obtain the desired effect. If you’re not getting the desired effect from a single dose, try gradually increasing how much you consume.
Another issue is that you might be using the wrong type of edible. Not all edibles are the same. The type of cannabis in the edible matters. Certain strains of cannabis are higher in THC while others are higher in CBD. The wrong ratio may impact your experience and cause you to not feel the effects that you were hoping for.
Your Body Metabolizes the THC Too Quickly
Edibles work differently than other types of cannabis. Whereas smoking, vaping, and placing tinctures under your tongue allow the cannabis to absorb directly into your bloodstream, edibles need to be digested first. THC is metabolized in your liver before being dispersed into your bloodstream. The enzymes in your liver play a significant role in your response to different cannabinoids. Having higher or lower CYP enzymes alter the rate of metabolism and may even mean that THC isn’t metabolized at all.
You’re Taking the Edible on an Empty Stomach
For some, edibles may cause them to feel something, but it isn’t the effect they were hoping for. Instead of feeling relaxed, you might feel incredibly anxious. One of the biggest reasons for this might be because you’re taking the edible on an empty stomach. While it still takes longer to hit your system than smoking or vaping, consuming an edible with nothing else in your stomach can cause the THC to hit you more quickly than if you eat beforehand and cause unwanted effects.
If you’re taking edibles on an empty stomach and getting the opposite of the desired effects, you might want to try eating a good meal and drinking plenty of water beforehand. Doing so slows the absorption and can help to keep you from getting overwhelmed by THC.
It Just May Not Be Suitable for You
For some, edibles simply just don’t work no matter what they do. Just like certain types of conventional medications don’t work for everyone, cannabis edibles just don’t work for everyone. Instead, you may want to consider trying a different type of cannabis. If you don’t want to smoke or vape, you could try a tincture.
While cannabis edibles can be an effective way for many people to enjoy the effects of cannabinoids without smoking or vaping, they’re not necessarily for everyone. If you’re not getting the desired effects from your edibles, speak with your dispensary for tips or to find something else that can help suit your needs.
Is the effect of a tincture the same as the effect of an edible?
Hi Erica, An edible, can take anywhere from 1 to 2 hours to take effect. A sublingual tincture will take effect withing 15-20 mins and last 4 to 5 hours.
I’m up to 150 mg and I still don’t feel anything. I was told the reason edibles don’t work for me is because I had my gallbladder removed about 12-13 years ago. Is this an actual fact or just know-it-all crap?
Hi Jane,
Thank you for reaching out. Everyone’s dose is different. When you state you are up to 150mg dose is that an edible dose or ?
I would recommend trying a sublingual infused cannabis product such as our tinctures or hard candy lozenges. Taking cannabis sublingually will by pass the GI tract and enter your system via the mouth tissue. Most patients feel the onset faster with sublingual’s and they do not need to take as much. Hope this helps! Good luck and be well.
Jane, a friend of mine had his gallbladder removed and edibles (even a small amount) affect him. Me though, while I have just a little trouble with building up tolerance to smoking, can’t seem to get edibles to work no matter how much I eat. I took 800 mg today and didn’t feel anything. :/
I have taken 200mg’s all at one time, with absolutely zero effect. I took an entire bottle of gummies (10 gummies at 10mg/dose) and a drink with the same dosages (10 doses at 10mg/dose. After a 1-1/2—2-hour train ride I tried a sublingual tincture with 10-20 doses and again felt absolutely nothing. I had doctors in Oregon tell me I was wasting my money because my liver did not have an enzyme to process the THCA into THC. My current doctor in Florida told me that was not true, that it was more of an absorption thing. So I bought a Magical Butter2 and proceeded to make my own edibles at higher doses. I felt absolutely nothing but when I had a couple of others sample to see if my cooking was wrong. Both of them had to go lay down on their bedroom floor for a few hours because they were absolutely blitzed. So I am guessing it is not a “simple absorption issue” for quite a few people like myself.
What I would like to know is if their is a supplement I can take that will act the same as the enzyme I’m missing. Maybe take it 20-30 minutes before an edible and it will allow the edibles to be processed by my body. Anyone have any thoughts about something like this?
Is there anyone who makes extra-strong doses of edibles for people who are resistant/tolerant &/or need above-average doses because of the severity of their conditions and tolerance to all other medications. Speaking just for myself, I have had 17 surgeries, amputations, bones removed, external fixators attached for months, etc etc etc, so almost any med they give me needs to essentially be doubled-up on either dosage or time.
When I started to smoke after getting my MMJ cars I do not get as blitzed as others so I know I had a natural tolerance even as a newbie. Even now I rarely get the munchies or any giggles but I do feel “lighter,” my physical pain goes down 2-3 notches, and I can get along with other people without wanting to throttle them like Homer Simpson does Bart so I know it works smoking, and to a lesser extent vaping, but anything else is a waste.
Does anyone have any sort of feedback, help, suggestions, etc? Or as we said in the Army — “comments? criticisms? cuss-words?” :^)
Clint, We reached out and asked one of the leading cannabinoid experts, Dr. Mary Clifton, MD about your situation. She mentioned that based on her work with other clients that you may want to consider, that you are likely resistant because of enzymatic levels that are breaking down the medication quickly, or more likely that you may have genetic differences in your CB 1 and 2 receptors (so people have more and some have less) and is just not getting that much stimulation regardless of the products that you are taking. It is nice that you are seeing decreased pain and feels lighter — especially after all those surgeries. We hope this helps you with suggestions and things to research and look into!
I suggest everybody here goes out and gets some concentrates (wax or hash oil/rosin/isolate crystals are a personal favorite along with rosin) and let me know your experience. Best thing I ever did and if you guys haven’t tried it but feel your spending a lot of money on weed and/ or going through it too quick, one gram of wax can last me up to a week and costs $30 a gram whereas I can spend $70 on a quarter of flower and it’ll last 3-4 days and it takes me back to when I first got high without a tolerance and personally I believe it’s what could save people from searching for something stronger and going to harder drugs. Kudos
i dont think its possible for me to get any sort of high off edibles. i ate a 600mg chocolate bar earlier after having a meal. its hours later and i barely feel a buzz. im a pretty heavy consumer, but im also only a 5’3, 98lb girl. it just makes no sense ?
How common is it for people to not have the enzyme that helps digest edibles? Me and my boyfriend have both tried edibles only twice now (we’re heavy smokers though) and we both haven’t felt anything either times. We don’t know if this is a tolerance thing, a biological thing, or maybe the edibles just weren’t strong enough? I’m not positive but I think the latest dud was supposed to be 150mg and we started by eating half of it, waited two hours and didn’t feel it so we each ate the other half and it still didn’t work. So essentially we both ate a full 150mg edible and didnt feel anything. Now I’m still a bit new to all of this stuff so I honestly don’t know if that’s a high dose or not? I’m just trying to figure out if this lack of enzyme thing is common and coincidentally happening to me and my boyfriend both, or if we just are t getting the right kind of edible for us.
Howdy Emily!
We are hearing more and more people sharing the same kind of experience. When you digest anything via your GI tract, stomach acids kill off a percentage of the cannabinods, once the cannabis passes into the small intestines where it should be absorb, there could be an absorption issue or lastly it could be that you may have alot of the enzymes in your liver and you are breaking down the cannabis to quickly. Some customers have found using a infused beverage or liquid is easier to digest and they feel the effects, others say that they use sublingual tinctures or smoking and by pass the GI tract with the cannabis directly entering the blood stream. One thing is for certain, if you ingested 150mg of cannabinods, and it was from a licensed shop where the edibles are TESTED for potency, you should of felt something.
Hope you find this helpful.
Lex,
you may want to read my reply to Emily regarding the same issue.
I had gastric bypass 10 years back. I first tried edibles a few years after the surgery and every time they have had almost no effect on me whatsoever, regardless of dosage. Even the most loaded-up of brownies do nothing for me. Granted, as of the last few years my THC tolerance has been quite high, but even that first time didn’t produce a reaction. I’ve always wondered whether there is a correlation between having gastric bypass/its effects on the body and the effectiveness of THC edibles.
How come when I make cannabis chocolate from scratch it doesn’t stay hard after refrigerating if it sits out for just a touch?
Same here Clint. Takes huge does for me to get high, 1200mg+ in any form. Been making my own, buying others, it’s just how it is for me. T breaks, all that never makes a real difference, comes right back in a few days.
I are about 600 mg or more of edibles and I’m not feeling anything it’s been like 4 hours? Not enough dosage I’m pretty small (5’2/ 120 p) don’t know how I’m not blazed right night.
Hi Amy!
The procedure you had does impact absorption in general in regards to nutrient’s as well as cannabis. I would suggest that for vitamin supplements AND cannabis to use a sublingual product that will be absorbed via your mouth tissue and not your GI tract such as our tinctures or hard lozenges. Hope this helps!
Amy Fairchild, MSCAM
So a few years back when I was 17 I ate my first edible and it kicked in withen the hour but now that I’m 23 and have eaten a edible it has no affect on me I’ve eaten 2-3 at once and nothing is there a reason why I was able to get high of edibles when I was younger and not now that I’m older ?
I’m thrilled to know that I’m not the only one this is happening too. I have 30mg capsules that I got from my dispensary after having zero effect from previous edibles. I took 10 of them! 300 mg and I do not feel a thing!! So annoying!
I usually take 100-200mg of thc when I do edibles, but I have yet to have any sort of reaction. I do have mild gastroparysis, so I was wondering if this could be why? I have a very high tolerance for thc when smoking or vaping and usually dab about 3 grams of wax concentrate per week. Is it possible I’m just not taking enough edibles because my tolerance is so high?
Hey so recently after a year without eating edibles I finally ate one 2 weeks ago and it didn’t have any affect not only that but I ate gummys and other tipe of edible to nothing I dont under stand why they dont work anymore befor I could eat a 50 mg and that used to be good but now nothing works why could that be?
I am a daily cannabis user. I use flower, concentrates, tinctures, etc. I’ve used it all for many years. I do have a high tolerance but do take tolerance breaks. I have never once had any edible work for me. Never. I have wasted thousands of dollars over the years trying. I have tried hundreds of different dispensary edibles as well as even home making. Same thing, my wife and friends and family all get high from exact edible I am taking. I take 20, they take 1. They are high, I feel nothing. Sublingually thc works for me. It’s only edibles. I still am stupid and waste time and money from time to time to see If my body has changed. It never has. I have never been given a real or straight answer on why. I love thc and it’s been super frustrating not being able to enjoy or feel anything from edibles. I would love to know the exact reason as there should be some way to counter this enzyme, or immulate it depending on if it is insufficient or over sufficient. Sounds like I’m not alone, but trust me edibles DO NOT work for me period. I’ve taking as much as 1,500 mg thc at once, and nothing. Had to hit my vape pen all night…… good luck to you all and hopefully we can find a real scientific answer
Howdy Laura,
It could be due to both your high tolerance and due to malabsorption in your GI tract as well. When you take a cannabis edible, the cannabis is broken down by your enzymes in your liver. You could have a very high amount of these enzymes which could be metabolizing the THC very quickly before the onset of the psycho-activity.
Hello! I found you by searching this question. I am a heavy frequent user (due to pain & other) I started edibles in August 2020.
My issue is, sometimes it works, sometimes not at all. I did discover that eating is important. I’m wondering if what we eat could have something to do with it.. ?
Thank you!
I took a 1500 mg brownie and didn’t feel anything aside from a small ditzyness
I had my gallbladder removed as a young teenanger. I also, do not get high off edibles. Scarfed down 500mg and nothing.
It’s the dispensaries. They sell garbage. I’ve made and eaten edibles for years, and if you slip up and eat too much you trip your face off for a day. The ‘new’ edibles are simply a lie. You can overdose on edibles, and the dispensaries don’t want any part of that. They make their products so weak that you would fill your stomach and start to vomit before getting too high. It’s a scam. Buy your edibles on the black market. That’s the only way you get the real deal.
I have been smoking weed and concentrates regularly for 20 years, but edibles have never worked on me. I once took 5,000mg at once with no results and had pretty much given up on them. I was out of weed recently and ate some gummies I had leftover from when my grandma was visiting (she was fighting cancer at the time and used edibles for pain relief). The damn things hit me hard and got me super high. The only thing that has changed since the last time I tried edibles is that I recently had my gallbladder removed. I’ve heard the rumor that people without gallbladders can’t get high on edibles, but I had the exact opposite experience. I wonder if it has something to do with a change in enzyme production after my gallbladder was removed.
Hi Brandon,
Thank you for sharing! It is true that edible regulations only allow legal edibles to be 10mg of THC per serving and 100mg THC per package/container. Before regulation, we used to make 500mg Red Velvet Brownies but unfortunately, they are no longer compliant. Cheers!
Cannabis oil is fat soluble. When you take an edible with food it may help absorption.
Hi I recently started trying the edibles at home with my canna butter I do not feel like thing I have a bad liver. Does that mean the tincture Will not work also I’m just trying to figure everything out I’m trying to bypass my liver and stomach you said some thing about candy
Hey everyone, after reading what everyone else had to say I too am in the same boat. No matter how many mgs of THC the edible has I don’t feel a thing. Now I’m kinda a new smoker per say. I actually used to not like weed at all, my first experience was brutal, severe paranoia and confusion and I just couldn’t wait for the feeling to end. Therefore I have hardly smoked much in my life but I have fortunately found a couple strains of bud that actually work for me, meaning they help my symptoms but I also catch a nice little buzz too, the problem is I also have difficulty finding strains that even work for me which sucks. Luckily the closest dispensary sells flower in 1g increments which is great to be able to try multiple different types without having to buy an eighth minimum. Anyway my question is can anyone else that deals with this apparent enzyme/genetic disorder recommend what works best for you and maybe what symptoms it helps relieve. Thanks for reading and any advice ?
I once took 150 mg of edibles and was zonked in about 90 mins and then had to sleep off in the next 2 hours. However I have tried edibles 4-5 times since then in varying quantities. Yesterday I went to 315 mg but didn’t feel a single thing. I’ve been a smoker for the past 6 years now. Do you have any information that could help me? How did I become resistant to edibles in a year?
Hello, I am a type 2 diabetic. When I eat Edibles, it does nothing. I was wondering if it was because of the insulin levels in my body? I take 1.8 mg of Victoza every day. Would this be the reason why Edibles do not have an effect on me? Could the sweetness of the edible be canceling out the THC? Thank you very much.
Howdy Ryan,
Thanks for your comment. There is no clinical research supporting this theory although it could possibly be impacting it.
I would suggest trying sublingual drops (tincture with THC) this by passes your GI track. If you experience the psycho- activity, then you can pretty much figure it is more of a absorption issue in the GI track causing edibles not to work.
Howdy Dalton, Thanks for your comment. Are your homemade edibles working for you? Make sure you are baking under 350 degrees not to burn off your cannabinods. Tinctures work sublingually, entering your system through your mouth tissue by passing GI track. You are also regulate and find your ideal dose much easier with a tincture do to the calibrated droppers and info on bottle. Dr. Raw manufactures hard candy lozenges that work sublingually as well if you let them dissolve in your mouth. They come in 3 formulas – FOCUS – high CBD, BALANCE 1;1 THC: CBD and RELAX 20:1 THC: CBD.
I’m wondering if I suck the gummy bears instead of chewing, would that bypass my liver? I have no gall bladder
Someone asked about bariatric surgery and if it effects edibles. My friend had a gastric bypass and he gets zonked on a 40 mg edible. For anyone having issues with edibles not working for them, I suggest trying rso. Either in oil form, which you can buy by the half or full gram in a syringe, or capsules. I started with the oil, which I have baked into brownies but now just put a dose of it in a spoon full of peanut butter. The capsules are a more exact dose and you can buy them in different mg dosages. The oil is cheaper per dose, bit tastes horrible.
What if I suck on the gummy bears? since my gastric bypass and removal of my gall blotter I can’t get high even smoking. I have tinctures and 25mg capsules and gummies . Spending $$$ and getting nuts!
I like (standard)gummies. And is always random when I get high. Even in does of 800mg. Help
Alma
Sublingual delivery may work but if smoking dose not deliver the affect you are looking for, I do not know if sublingual will.
You enzymes in your liver might be breaking down the THC so fast that is prohibiting the high.
I think my issue is absorption because no matter how much I ingest I get no results. I have celiac disease & I’m wondering if its connected.
Tammy
Yes, with Celiac disease malabsorption is definitely a problem. Sublingual cannabis options or smoking, dabbing or topical for spot treatment of pain would be your best considerations.
Alma, it all depends if the gummy would dissolve in your mouth completely. There are sublingual edibles. For example, we manufacture hard candy lozenges that dissolve in your mouth and are made for sublingual application.
I’ve personally tried over 10 different types of edibles and not a single one of them made me feel a thing, I do smoke everyday as it helps a lot with my type 1 diabetic symptoms like being nauseous or not being hungry. Also I have asked around and both my mother and father have taken edibles and same results , they feel nothing . They also smoke everyday but I’m wondering could these be a genetic type thing even if I didn’t smoke I feel like after reading everyone’s comments I bet this is a genetic thing! Also why isn’t diabetes on the list of medicinal marijuana! A different subject but the results are undeniably terrific and so helpful for a lot of my symptoms (restless leg syndrome, mood swings due to blood glucose levels constantly changing, etc.
Gallbladder removed about two years ago.
They’ve always been weak for me unless they were made really strong. Got worse qfter surgery. I ate 1100 mgs the other day and didn’t feel high at all.
Hi I have an eating disorder Anexoria and bulimia to be specific and I have about 3 60mg gummies and felt nothing I read somewhere that I didn’t get high because of my EDs is this true?
thanks
Mark, Thanks for your comment. When edibles DO NOT work, its either malabsorption or an increased amount of the enzymes in your liver that metabolize the THC quickly not allowing the psycho-activity. Smoking by passes the GI tract and goes directly into the blood via the lungs.
I ate 1000mg with no effect at all is there something wrong with me or what
I ate an edible with 600 mg of thc and 2 hours later nothing is happening. I want to know if it has anything to do with my thc intake when vaping.
My problem has been of the 8 times ive done edibles only twice have i felt them. I have no gallbladder either but from what ive read its either enzymes or stomach acids cooking of the thc. My question i guess, what can i do to help the absorption of the thc thru the digestive tract? Thank you
Edibles do not do a thing for me, and I had suspected my liver enzymes were to blame.
Acetaminophen has also never really worked (even at prescription strength), nor has Ibuprofen. When I eat asparagus, I have never experienced that awful smell.
Edibles used to work great for me but now do nothing. Until two weeks ago I was a heavy and daily drinker. Could it be liver damage/issues that are causing the lack of effectiveness of the edibles? Is it possible with time and healing of my liver edibles will work again? Smoking and vaping work but I do have a high tolerance. I bought a tincture and it really doesn’t do much if anything.
I’ve been smoking dabs for almost 8 years now. Go thru a gram of concentrate every two days. With that said, I don’t get anything off any other way of doing cannabis no matter the dosage. I don’t feel literally anything at all off cannabis unless I’m dabbing it.
Some people add fat to the edible since cannabis is fat soluable and they say that helps the absorption. Others try the cannabis drinks and syrups, try the nano edibles or try sublingual edibles like hard lozenges or 1000mg tinctures – the cannabis enters your system via your mouth tissue and by passes your GI tract.
To Clint and many people who have very high tolerance for everything, I can understand the process of the body who has been by many traumas like many of you..5 years ago, before cancer, I could just smoke a joint a drink a glass of wine, and the high was always there my entire life..
after chime and radiation, I survived everything, but I can smoke weed all evening feel nothing, I tried the vape it was nice to get high again, but it quickly stopped being too weak for my body, so I can relay to you guys, because I wish they would make a mega strong spliff so grandmas can sleep again and dream,,xoxo
I’ve eaten 5 100mg brownies with very little effects at all. Still went to work and did everything normally. Maybe felt a little less stressed when things picked up but that’s it. I wish I could enjoy an edible buzz.
I can eat a whole bag of gummies and nothing happens. My friend got super high off of like 2 and tried to make out with me though lol
I’m at 1000mg right now and nothing, sucks because I want to save my lungs. I do smoke a lot, and I drink alcohol too. Either I destroyed the enzyme with alcohol, or my liver is now SUPER and has built up a tolerance to everything. -Anyway, I may try a tincture, but doubtful. I just like “healthy” ways to get high.
I’ve heard taking the digestive enzyme supplement prior to eating an edible will help. I know people who take it and then get high off 10mg
Hey, so I have never had any noticeable effects from any edible before. I was involved in an accident that resulted in the removal of one of my kidneys and my spleen; could that be the reason?
I have always been curious about this subject and would love some feedback!
Thank you.
I have been trying everything. Tincture, distillate, RSO, and I’ve baked a ton of edibles. I literally ate 860mg of distillate with some fatty milk and a fatty meal. I felt nothing. I apparently have a super power, and it’s the worst one ever. My next attempt, which for most people would be dangerous, will be 1,500mg. Oh and yes.. all was decarbed.
Howdy Adam
Research states that the reason for this maybe due to your lover enzymes that metabolize Cannabis. It breaks it down before you can get the side effects, the ‘high” . Smoking, vaping and sublingual application that by passes the liver maybe the best option for you.
Howdy Drew
When you ingest a cannabis edible it is your liver that metabolizes the Cannabis as well as absorption in the small intestine. I would ask your doctor if having lost one Kidney and spleen, could impact your digestion of cannabis but based on what I have read it is mainly up to your liver and small intestine. Cannabis is fat soluble, hence it could have something to do with how you breakdown fats. You may want to try some of the infused beverages, or edibles that have NANO technology, which makes the THC molecule smaller and easier for your body to absorb or stick with smoking, vaping, dabbing or sublingual application like tinctures which all bypass your GI tract.
love that suggestion!
Made cannabutter. 7grams19% bud and 11/2 stick butter. Friends got high me a little noticeable. ??
I am new to all of this. Got an RX for chronic pain and to neck get off sleep meds. I got gummies and tincture. Gummies made me wired, not at ask relaxed, but my legs felt funny so couldn’t do anything. Tincture did nothing at all.
Two of my doctors commented that I’m one of the ones it doesn’t work on. Said it’s quite common. Neither thought it was worth it to try different things or doses. Meanwhile still nothing for the pain (I’ve tapered off opioids and stomach can’t have NSAIDs anymore. And still can’t sleep. Any suggestions?
Cannabis-infused nut butter is the ONLY thing that works for me, I’ve tried everything else. Found it commercially made at a dispensary once, can’t find it anymore so I make my own. Such a nuisance, but effective. Decarb, bake with unsalted smooth almond or peanut butter, add a little olive oil; recipes are on the web.
**HELP** I get total relief of my anxiety, depression, insomnia, stomach ulcer, and random body pains, all from simply smoking/vaping the flower. It saves me from otherwise taking SIX different prescriptions.
I’ve an insane tolerance, by the way, due to frequency.
…HOWEVER…,
I’m one of those who can’t seem to get ANY effect from edibles. Knowing this, I once put it to the test BIG TIME. I took 1000 MG (10 various ingestibles, 100 mg each; candies, gummies, liquid drink, chocolate, brownie, cookie, etc…) alllllll at once. I wanted to know, so I literally downed all 1000 MG at the same time! …still felt nothing.
Is it just an enzyme issue? If so, how can I correct it?
Cannabis is literally a life-saver for me, miraculously curing ALL my issues, helping me function at 100%, so I’m able to hold down my responsibilities, exercise, sleep, and feel much, much better. It’s a miracle plant!!
…but I fear what it might do to my lungs over time, so I really need to find out how to get any oral version to work for me.
I’m a health & fitness junkie…gym, yoga, kickboxing, Jiu-Jitsu, etc… In fact, I’m a very successful personal trainer and motivator of others. But sadly, without cannabis I suffer from a variety of ailments.
Can anyone offer any (educated) suggestions????
I’ve heard taking antacids. I’ve also heard the opposite, which makes it confusing.
Anyone have any clues???
Thank you,
Love & Light to all…
I have the same problem with edibles – little or no effect even at high doses. I thought it was just that I did not prepare them correctly. I have tried up 400 mg of delta-8-THC, with no effect. My girlfriend, who has only rarely smoked cannabis, was stoned on 10 mg delta-8. (I know that delta-8 is not the same as the classic delta-9 found in cannabis.)
Though I am not an addict, narcotics like Vicadin have almost no effect on me, even at doses that should have been very strong. I was tested to have a mutation in my CYP enzymes that makes narcotics almost worthless. Approximately 5% of the population has this problem. I suspect that problem is the cause for edibles not working
Genetics and Enzymes impact how you metabolize THC. A gene called CYP2C9 makes an enzyme that breaks down THC (the main psychoactive ingredient in cannabis). Variations in this gene can cause a 3-fold difference in your ability to metabolize THC. Studies have shown that this can cause differences in how long-lasting and intense the effects of pot are for different people.
Also, your CYP2C9 variant may help predict how long you have to wait to pass a drug test after consuming cannabis, with certain genetic variants only needing a few days to clear the relevant molecule from their system and others needing up to 30 days.
Ingestion THC:
When ingested, delta-9-THC enters the bloodstream through the walls of the stomach and intestines. Tests with radiolabeled delta-9-THC molecules show this process to be highly effective, with 90-95% of delta-9-THC molecules being absorbed, depending on the carrier medium.3 When absorbed gastrointestinally, delta-9-THC travels first to the liver where most of it is eliminated or metabolized before it has ever had a chance to activate a receptor. After this first pass through the liver, the remaining delta-9-THC and both its metabolites get to the heart and from there into circulation. Delta-9-THC and 11-OH-THC reach the brain simultaneously.
For ingested delta-9-THC, bioavailability is only between 4-12%. In contrast to inhalation, the user has little influence on the degree of bioavailability, with the exception of choosing a more optimal carrier medium. In many studies the choice was sesame oil or a similar high-fat carrier. After oral use, high variability was observed not only in the absolute levels of THC but also in the timing when users show peak concentration. Concretely, person A can exhibit peak concentration after one hour of ingestion whereas person B can exhibit peak concentration after six hours. Multiple peaks have been reported as well.
While no studies have directly examined those with ultra-high tolerances to marijuana edibles, Gruber and other researchers have a compelling hypothesis: People with an unusual variation of a key liver enzyme could essentially be too efficient at processing ingested THC, turning the compound into its “active” high-causing metabolite and then its inactive waste product before the active form can enter the bloodstream or brain. It’s also possible other people’s enzymes make them unusually inefficient at performing this process, with little THC getting metabolized in the first place. People with uncommon subtypes of the CPY2C9 gene, which encodes the enzyme that shepherds THC through its three-step metabolic transformation. “You’re breaking it down so fast it doesn’t have an opportunity to create the psychoactive effect.” Scientists add that other variables such as how easily people absorb and metabolize fat probably play a role, too.
Becky, for the sleep, customer’s like our 1000mg RELAX 20:1 tincture to be taken 20 minutes before desired sleep. I am not sure what tincture and ratio you tried in the past nor what dose you took. Finding your dose is what would be the hardest, since we are all different.
HI, I’m new to edibles, tried 64mg (4 x 16mg gummy bears), no effect, then tried 6 more, still no effect. The next night I eat 10 of these gummy bears so a 160mg in total, still nothing.
Last night I eat 1200mg (4 x 300mg fish tails). Apart from a little buzz which may have been left from what I had been vaping throughout the day, I felt nothing. After 3 hours I felt more or less straight and had to take a hit from my Plenty Vaporizer to get high.
I have noticed a lot of talk about liver enzymes. I sadly abused alcohol for years, in my teens and 20s. Would this be the issue? I have been dry for almost 10 years (OCT 4th) and have had numerous blood tests for liver function which have all come back ok.
Guess I stick to my Plenty and PAX 3 Vapes. Would butter be better?
Summary: The amount of each type of CYP enzyme (specifically CYP2C9 & CYP3A4) you have in your liver is determined by specific genes, your DNA. These are not the same as digestive enzymes, you can’t take these enzymes in a pill or supplement form. Not much can be done to effect the problem except for using SUBLINGUALS because they bypass the liver & 1st pass liver metabolization by going straight to your bloodstream just like smoking or an IV.
I have never used cannabis before but felt nothing on 1200 mg of Tincture, gummies, sour patch candy with no psych effects. HELP